Synthetic studies related to MPC1001: formation of a model epidithiodiketopiperazine

Publication year: 2012 Source: Tetrahedron Letters, Available online 21 January 2012 Lihong Wang, D.L.J. Clive A tricyclic epidithiodiketopiperazine was prepared having structural features related to the antitumor antibiotic MPC1001. The method is based on the use of the sulfenylating agentp-MeC6H4S(O2)SCH2OSiMe2Bu-tto introduce two protected sulfur atoms in a sequential and stereocontrolled manner

Publication year: 2012 Source: Tetrahedron Letters, Available online 21 January 2012 Lihong Wang, D.L.J. Clive A tricyclic epidithiodiketopiperazine was prepared having structural features related to the antitumor antibiotic MPC1001. The method is based on the use of the sulfenylating agentp-MeC6H4S(O2)SCH2OSiMe2Bu-tto introduce two protected sulfur atoms in a sequential and stereocontrolled manner

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Synthetic studies related to MPC1001: formation of a model epidithiodiketopiperazine