Simvastatin disrupts cytoskeleton and decrease cardiac fibroblast adhesion, migration and viability

Publication year: 2012 Source: Toxicology, Available online 28 January 2012 Miguel Copaja, Daniel Venegas, Pablo Aranguiz, Jimena Canales, Raul Vivar, … Statins reduces the isoprenoids farnesyl and geranylgeranyl pyrophosphate, essential intermediates, which control a diversity of cellular events such as cytoskeleton integrity, adhesion, migration and viability. Cardiac fibroblasts are the major non-myocyte cell constituent in the normal heart, and play a key role in the maintenance of extracellular matrix.

Publication year: 2012 Source: Toxicology, Available online 28 January 2012 Miguel Copaja, Daniel Venegas, Pablo Aranguiz, Jimena Canales, Raul Vivar, … Statins reduces the isoprenoids farnesyl and geranylgeranyl pyrophosphate, essential intermediates, which control a diversity of cellular events such as cytoskeleton integrity, adhesion, migration and viability. Cardiac fibroblasts are the major non-myocyte cell constituent in the normal heart, and play a key role in the maintenance of extracellular matrix.

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Simvastatin disrupts cytoskeleton and decrease cardiac fibroblast adhesion, migration and viability