Passenger mutations as a marker of clonal cell lineages in emerging neoplasia

Publication year: 2010 Source: Seminars in Cancer Biology, Volume 20, Issue 5, October 2010, Pages 294-303 Jesse J. Salk, Marshall S. Horwitz Cancer arises as the result of a natural selection process among cells of the body, favoring lineages bearing somatic mutations that bestow them with a proliferative advantage. Of the thousands of mutations within a tumor, only a small fraction functionally drive its growth; the vast majority are mere passengers of minimal biological consequence

Publication year: 2010 Source: Seminars in Cancer Biology, Volume 20, Issue 5, October 2010, Pages 294-303 Jesse J. Salk, Marshall S. Horwitz Cancer arises as the result of a natural selection process among cells of the body, favoring lineages bearing somatic mutations that bestow them with a proliferative advantage. Of the thousands of mutations within a tumor, only a small fraction functionally drive its growth; the vast majority are mere passengers of minimal biological consequence

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Passenger mutations as a marker of clonal cell lineages in emerging neoplasia