Clinical Correlates of Hemoconcentration During Hospitalization for Acute Decompensated Heart Failure

Publication year: 2011 Source: Journal of Cardiac Failure, Available online 3 September 2011 Carlos Davila, Alex Reyentovich, Stuart D. Katz BackgroundHemoconcentration has been proposed as a putative biomarker of effective decongestion therapy in heart failure patients. The prevalence and clinical correlates of hemoconcentration in hospitalized patients with acute decompensated heart failure (ADHF) have not been previously described.Methods and ResultsWe retrospectively reviewed paired values of hemoglobin at admission and discharge to identify evidence of hemoconcentration in 295 subjects hospitalized with ADHF and determined the association between hemoconcentration and risk of worsening renal function and survival. Subjects with hemoconcentration (n = 75) received higher diuretic doses and demonstrated greater weight loss during hospitalization when compared with subjects without hemoconcentration (median [IQR] loop diuretic dose 180 (120) versus 160 (150) mg,P = .014; mean ± SD weight loss 4.0 ± 3.1 versus 2.2 ± 3.1 kg,P < .001)

Publication year: 2011 Source: Journal of Cardiac Failure, Available online 3 September 2011 Carlos Davila, Alex Reyentovich, Stuart D. Katz BackgroundHemoconcentration has been proposed as a putative biomarker of effective decongestion therapy in heart failure patients. The prevalence and clinical correlates of hemoconcentration in hospitalized patients with acute decompensated heart failure (ADHF) have not been previously described.Methods and ResultsWe retrospectively reviewed paired values of hemoglobin at admission and discharge to identify evidence of hemoconcentration in 295 subjects hospitalized with ADHF and determined the association between hemoconcentration and risk of worsening renal function and survival. Subjects with hemoconcentration (n = 75) received higher diuretic doses and demonstrated greater weight loss during hospitalization when compared with subjects without hemoconcentration (median [IQR] loop diuretic dose 180 (120) versus 160 (150) mg,P = .014; mean ± SD weight loss 4.0 ± 3.1 versus 2.2 ± 3.1 kg,P < .001)

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Clinical Correlates of Hemoconcentration During Hospitalization for Acute Decompensated Heart Failure