TheMYCNoncogene and differentiation in neuroblastoma

Publication year: 2011 Source: Seminars in Cancer Biology, Available online 9 August 2011 Ulrica K. Westermark, Margareta Wilhelm, Anna Frenzel, Marie Arsenian Henriksson Childhood neuroblastoma exhibits a heterogeneous clinical behavior ranging from low-risk tumors with the ability to spontaneously differentiate and regress, to high-risk tumors causing the highest number of cancer related deaths in infants. Amplification of theMYCNoncogene is one of the few prediction markers for adverse outcome. This gene encodes the MYCN transcriptional regulator predominantly expressed in the developing peripheral neural crest

Publication year: 2011 Source: Seminars in Cancer Biology, Available online 9 August 2011 Ulrica K. Westermark, Margareta Wilhelm, Anna Frenzel, Marie Arsenian Henriksson Childhood neuroblastoma exhibits a heterogeneous clinical behavior ranging from low-risk tumors with the ability to spontaneously differentiate and regress, to high-risk tumors causing the highest number of cancer related deaths in infants. Amplification of theMYCNoncogene is one of the few prediction markers for adverse outcome. This gene encodes the MYCN transcriptional regulator predominantly expressed in the developing peripheral neural crest

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TheMYCNoncogene and differentiation in neuroblastoma

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