The p53-p21checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function

Publication year: 2011 Source: Cellular Signalling, Available online 21 September 2011 Pang-Kuo Lo, Ji Shin Lee, Saraswati Sukumar We previously identifiedFOXF1as a potential tumor suppressor gene with an essential role in preventing DNA rereplication to maintain genomic stability, which is frequently inactivated in breast cancer through the epigenetic mechanism. Here we further addressed the role of the p53-p21checkpoint pathway in DNA rereplication induced by silencing of FOXF1. Knockdown of FOXF1 by small interference RNA (siRNA) rendered colorectal p53-null and p21-null HCT116 cancer cells more susceptible to rereplication and apoptosis than the wild-type parental cells

Publication year: 2011 Source: Cellular Signalling, Available online 21 September 2011 Pang-Kuo Lo, Ji Shin Lee, Saraswati Sukumar We previously identifiedFOXF1as a potential tumor suppressor gene with an essential role in preventing DNA rereplication to maintain genomic stability, which is frequently inactivated in breast cancer through the epigenetic mechanism. Here we further addressed the role of the p53-p21checkpoint pathway in DNA rereplication induced by silencing of FOXF1. Knockdown of FOXF1 by small interference RNA (siRNA) rendered colorectal p53-null and p21-null HCT116 cancer cells more susceptible to rereplication and apoptosis than the wild-type parental cells

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The p53-p21checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function

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