Synthesis of Novel DNA-Interacting Phthalocyanines

Publication year: 2011 Source: Dyes and Pigments, Available online 14 December 2011 Canan Uslan, B. Şebnem Sesalan The new copper hexamethyleneimino-ethoxy substituted phthalocyanine (pc) (2) and its quaternized derivative (2Q) were synthesized. The interaction of quaternized copper (2Q), quaternized cobalt (3Q) and zinc (4Q) phthalocyanines (pcs) with calf thymus (CT) DNA was investigated by UV/vis spectrophotometric methods and gel electrophoresis. With the addition of pcs, the change in the thermal denaturation profile of DNA was observed.

Publication year: 2011 Source: Dyes and Pigments, Available online 14 December 2011 Canan Uslan, B. Şebnem Sesalan The new copper hexamethyleneimino-ethoxy substituted phthalocyanine (pc) (2) and its quaternized derivative (2Q) were synthesized. The interaction of quaternized copper (2Q), quaternized cobalt (3Q) and zinc (4Q) phthalocyanines (pcs) with calf thymus (CT) DNA was investigated by UV/vis spectrophotometric methods and gel electrophoresis. With the addition of pcs, the change in the thermal denaturation profile of DNA was observed.

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Synthesis of Novel DNA-Interacting Phthalocyanines