Genetic Engineering & Biotechnology News are reporting: Studies Overturn Premise that Growth Factors Are Best Approach to Healing Chronic Wounds Quote: Scientists say the widely held belief that growth factors represent the best treatment strategy for promoting healing in chronic wounds may be misplaced. They have found that a heat shock protein secreted by both human dermal fibroblasts (HDFs) and human keratinocytes (HKs) as a result of injury is key to removing a natural block to the migration of reparative dermal cells into the wound, effectively speeding cellular infiltration and wound repair and revascularization. Reporting their findings in the Journal of Clinical Investigation, researchers at the University of Southern California Keck School of Medicine and the Fourth Military Medical University’s Xijing Hospital describe a series of experiments demonstrating that single topical administration of a functional Hsp90α fragment overrides a natural TGF-β3-mediated barrier that would otherwise prevent HDF and human microvascular endothelial cells (HDMEC) from migrating into wounds until levels of the Hsp90α protein reach a certain threshold
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Studies Overturn Premise that Growth Factors Are Best Approach to Healing Chronic Wounds