Structural basis for specificity of TGFβ family receptor small molecule inhibitors

Publication year: 2011 Source: Cellular Signalling, Available online 1 October 2011 Abiodun A. Ogunjimi, Elton Zeqiraj, Derek Ceccarelli, Frank Sicheri, Jeffrey L. Wrana, … Transforming growth factor-β (TGFβ) receptor kinase inhibitors have a great therapeutic potential. SB431542 is one of the mainly used kinase inhibitors of the TGFβ/Activin pathway receptors, but needs improvement of its EC50(EC50 = 1 μM) to be translated to clinical use.

Publication year: 2011 Source: Cellular Signalling, Available online 1 October 2011 Abiodun A. Ogunjimi, Elton Zeqiraj, Derek Ceccarelli, Frank Sicheri, Jeffrey L. Wrana, … Transforming growth factor-β (TGFβ) receptor kinase inhibitors have a great therapeutic potential. SB431542 is one of the mainly used kinase inhibitors of the TGFβ/Activin pathway receptors, but needs improvement of its EC50(EC50 = 1 μM) to be translated to clinical use.

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Structural basis for specificity of TGFβ family receptor small molecule inhibitors

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