Statins Do Not Significantly Affect Muscle Sympathetic Nerve Activity in Humans With Nonischemic Heart Failure: A Double-Blind Placebo-Controlled…

Publication year: 2011 Source: Journal of Cardiac Failure, Available online 3 September 2011 Tamara B. Horwich, Holly R. Middlekauff, W. Robb Maclellan, Gregg C. Fonarow BackgroundHydroxymethylglutaryl–coenzyme A reductase inhibitors (statins) have been shown to reduce sympathetic nervous system (SNS) activation in experimental heart failure (HF). However, this potential mechanism of action of statins in HF has not been well studied in humans.Methods and ResultsTwenty-six patients with nonischemic systolic HF (left ventricular ejection fraction [LVEF] ≤35%) were randomized to atorvastatin (10 mg) or placebo for 3 months

Publication year: 2011 Source: Journal of Cardiac Failure, Available online 3 September 2011 Tamara B. Horwich, Holly R. Middlekauff, W. Robb Maclellan, Gregg C. Fonarow BackgroundHydroxymethylglutaryl–coenzyme A reductase inhibitors (statins) have been shown to reduce sympathetic nervous system (SNS) activation in experimental heart failure (HF). However, this potential mechanism of action of statins in HF has not been well studied in humans.Methods and ResultsTwenty-six patients with nonischemic systolic HF (left ventricular ejection fraction [LVEF] ≤35%) were randomized to atorvastatin (10 mg) or placebo for 3 months

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Statins Do Not Significantly Affect Muscle Sympathetic Nerve Activity in Humans With Nonischemic Heart Failure: A Double-Blind Placebo-Controlled…

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