These interesting data from teams at USC and Xijing Hospital / Fourth Military Medical University based on work just published in JCI. Scientists say the widely held belief that growth factors represent the best treatment strategy for promoting healing in chronic wounds may be misplaced. They have found that a heat shock protein secreted by both human dermal fibroblasts (HDFs) and human keratinocytes (HKs) as a result of injury is key to removing a natural block to the migration of reparative dermal cells into the wound, effectively speeding cellular infiltration and wound repair and revascularization
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Shock the Ulcer to Life: Do Heat Shock Proteins Trump Growth Factors in Wound Healing?