Selecting optimal conditions for Alcalase CLEA-OM for synthesisof dipeptides in organic media

Publication year: 2011 Source: Journal of Molecular Catalysis B: Enzymatic, Available online 17 November 2011 P. Vossenberg, H.H. Beeftink, T. Nuijens, M.A. COHEN Stuart, J. Tramper In protease-catalyzed peptide synthesis, the availability of water is essential, asa compromise must be made between on the one handthe overall enzymatic activity and, on the other hand, the rate of product synthesis.Water is essential for enzyme activity, but at the same time causes hydrolytic side reactions

Publication year: 2011 Source: Journal of Molecular Catalysis B: Enzymatic, Available online 17 November 2011 P. Vossenberg, H.H. Beeftink, T. Nuijens, M.A. COHEN Stuart, J. Tramper In protease-catalyzed peptide synthesis, the availability of water is essential, asa compromise must be made between on the one handthe overall enzymatic activity and, on the other hand, the rate of product synthesis.Water is essential for enzyme activity, but at the same time causes hydrolytic side reactions

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Selecting optimal conditions for Alcalase CLEA-OM for synthesisof dipeptides in organic media