Procalcitonin gene expression after LPS stimulation in the porcine animal model

Publication year: 2011 Source: Research in Veterinary Science, Available online 14 October 2011 Augusta Zannoni, Massimo Giunti, Chiara Bernardini, Fabio Gentilini, Andrea Zaniboni, … Procalcitonin (PCT), recognised as a marker of sepsis, was investigated in a porcine model of endotoxic shock.The results showed that continuous IV infusion (1–4 h) of LPS (40 μg/kg) in pigs was able to induce a generalised increase of PCT expression in lung, heart, kidney and liver. The increase in PCT was significant only in kidney and was accompanied by an increase in IL-6 gene expression.In vitroresults demonstrated that peripheral blood mononuclear cells (PBMCs), as well as endothelial cells, were potentially capable of contributing toin vivoextrathyroidal PCT production.

Publication year: 2011 Source: Research in Veterinary Science, Available online 14 October 2011 Augusta Zannoni, Massimo Giunti, Chiara Bernardini, Fabio Gentilini, Andrea Zaniboni, … Procalcitonin (PCT), recognised as a marker of sepsis, was investigated in a porcine model of endotoxic shock.The results showed that continuous IV infusion (1–4 h) of LPS (40 μg/kg) in pigs was able to induce a generalised increase of PCT expression in lung, heart, kidney and liver. The increase in PCT was significant only in kidney and was accompanied by an increase in IL-6 gene expression.In vitroresults demonstrated that peripheral blood mononuclear cells (PBMCs), as well as endothelial cells, were potentially capable of contributing toin vivoextrathyroidal PCT production.

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Procalcitonin gene expression after LPS stimulation in the porcine animal model

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