Lesions of the rat entopeduncular nucleus further deteriorates N-methyl-D-aspartate receptor antagonist-induced deficient prepulse inhibition

Publication year: 2011 Source: Neuroscience Letters, Available online 13 December 2011 Götz Lütjens, Joachim K. Krauss, K. Schwabe Lesions of the rat entopeduncular nucleus (EPN), the equivalent to the human globus pallidus internus (GPi), have been shown to improve deficient prepulse inhibition (PPI) induced by the dopamine agonist apomorphine. We here tested the effect of EPN lesions on the PPI-disruptive effect of the non-competitive NMDA receptor antagonist dizocilpine in rats.Neurotoxic bilateral lesions of the EPN were induced by ibotenic acid (4 μg in 0.4 μl).

Publication year: 2011 Source: Neuroscience Letters, Available online 13 December 2011 Götz Lütjens, Joachim K. Krauss, K. Schwabe Lesions of the rat entopeduncular nucleus (EPN), the equivalent to the human globus pallidus internus (GPi), have been shown to improve deficient prepulse inhibition (PPI) induced by the dopamine agonist apomorphine. We here tested the effect of EPN lesions on the PPI-disruptive effect of the non-competitive NMDA receptor antagonist dizocilpine in rats.Neurotoxic bilateral lesions of the EPN were induced by ibotenic acid (4 μg in 0.4 μl).

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Lesions of the rat entopeduncular nucleus further deteriorates N-methyl-D-aspartate receptor antagonist-induced deficient prepulse inhibition