Integrating synaptic plasticity and striatal circuit function in addiction

Publication year: 2011 Source: Current Opinion in Neurobiology, Available online 12 October 2011 Brad A Grueter, Patrick E Rothwell, Robert C Malenka Exposure to addictive drugs causes changes in synaptic function within the striatal complex, which can either mimic or interfere with the induction of synaptic plasticity. These synaptic adaptations include changes in the nucleus accumbens (NAc), a ventral striatal subregion important for drug reward and reinforcement, as well as the dorsal striatum, which may promote habitual drug use

Publication year: 2011 Source: Current Opinion in Neurobiology, Available online 12 October 2011 Brad A Grueter, Patrick E Rothwell, Robert C Malenka Exposure to addictive drugs causes changes in synaptic function within the striatal complex, which can either mimic or interfere with the induction of synaptic plasticity. These synaptic adaptations include changes in the nucleus accumbens (NAc), a ventral striatal subregion important for drug reward and reinforcement, as well as the dorsal striatum, which may promote habitual drug use

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Integrating synaptic plasticity and striatal circuit function in addiction

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