Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: Sustained activation of the TRPA1 channel contributes…

Publication year: 2011 Source: Pharmacological Research, Available online 23 November 2011 Ari Koivisto, Mika Hukkanen, Marja Saarnilehto, Hugh Chapman, Katja Kuokkanen, … Peripheral diabetic neuropathy (PDN) is a devastating complication of diabetes mellitus (DM). Here we test the hypothesis that the transient receptor potential ankyrin 1 (TRPA1) ion channel on primary afferent nerve fibers is involved in the pathogenesis of PDN, due to sustained activation by reactive compounds generated in DM

Publication year: 2011 Source: Pharmacological Research, Available online 23 November 2011 Ari Koivisto, Mika Hukkanen, Marja Saarnilehto, Hugh Chapman, Katja Kuokkanen, … Peripheral diabetic neuropathy (PDN) is a devastating complication of diabetes mellitus (DM). Here we test the hypothesis that the transient receptor potential ankyrin 1 (TRPA1) ion channel on primary afferent nerve fibers is involved in the pathogenesis of PDN, due to sustained activation by reactive compounds generated in DM

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Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: Sustained activation of the TRPA1 channel contributes…