Publication year: 2011 Source: Seminars in Cancer Biology, Available online 28 September 2011 Robert C. Seeger PurposeThis review demonstrates the importance of immunobiology and immunotherapy research for understanding and treating neuroblastoma Principal results The first suggestions of immune system-neuroblastoma interactions came from in vitro experiments showing that lymphocytes from patients were cytotoxic for their own tumor cells and from evaluations of tumors from patients that showed infiltrations of immune system cells. With the development of monoclonal antibody (mAb) technology, a number of mAbs were generated against neuroblastoma cells lines and were used to define tumor associated antigens. Disialoganglioside (GD2) is one such antigen that is highly expressed by virtually all neuroblastoma cells and so is a useful target for both identification and treatment of tumor cells with mAbs
Immunology and Immunotherapy of Neuroblastoma
Publication year: 2011 Source: Seminars in Cancer Biology, Available online 28 September 2011 Robert C. Seeger PurposeThis review demonstrates the importance of immunobiology and immunotherapy research for understanding and treating neuroblastoma Principal results The first suggestions of immune system-neuroblastoma interactions came from in vitro experiments showing that lymphocytes from patients were cytotoxic for their own tumor cells and from evaluations of tumors from patients that showed infiltrations of immune system cells. With the development of monoclonal antibody (mAb) technology, a number of mAbs were generated against neuroblastoma cells lines and were used to define tumor associated antigens. Disialoganglioside (GD2) is one such antigen that is highly expressed by virtually all neuroblastoma cells and so is a useful target for both identification and treatment of tumor cells with mAbs