Functional interactions between the oxytocin receptor and the β2-adrenergic receptor: Implications for ERK1/2 activation in human myometrial cells

Publication year: 2011 Source: Cellular Signalling, Available online 21 September 2011 Paulina K. Wrzal, Eugénie Goupil, Stéphane A. Laporte, Terence E. Hébert, Hans H. Zingg The Gq-coupled oxytocin receptor (OTR) and the Gs-coupled β2-adrenergic receptor (β2AR) are both expressed in myometrial cells and mediate uterine contraction and relaxation, respectively. The two receptors represent important pharmacological targets as OTR antagonists and β2AR agonists are used to control pre-term uterine contractions

Publication year: 2011 Source: Cellular Signalling, Available online 21 September 2011 Paulina K. Wrzal, Eugénie Goupil, Stéphane A. Laporte, Terence E. Hébert, Hans H. Zingg The Gq-coupled oxytocin receptor (OTR) and the Gs-coupled β2-adrenergic receptor (β2AR) are both expressed in myometrial cells and mediate uterine contraction and relaxation, respectively. The two receptors represent important pharmacological targets as OTR antagonists and β2AR agonists are used to control pre-term uterine contractions

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Functional interactions between the oxytocin receptor and the β2-adrenergic receptor: Implications for ERK1/2 activation in human myometrial cells

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