Evaluation of acetylcysteine promoting effect on CdTe nanocrystals photoluminescence by using a multipumping flow system

Publication year: 2012 Source: Talanta, Available online 14 February 2012 Christian Frigerio, Vera L.R.G. Abreu, João L.M. Santos A simple and straightforward quantification method integrated in a fully automated multi-pumping flow system (MPFS) using water-soluble mercaptopropionic acid (MPA)-capped CdTe quantum dots (QDs) was implemented for the fluorescence quantification ofN-acetyl-L-cysteine (NAC) in pharmaceutical formulations. The developed approach was based on NAC ability to establish surface interactions that result in enhanced nanocrystals fluorescence intensity, proportional to analyte concentration. Size and concentration of QDs, ageing, composition, concentration and pH of the buffer solution revealed to have a noticeable effect on the enhancing efficiency affecting sensitivity and linear working range of the methodology.Under the optimal conditions, a linear working range was obtained for NAC concentrations ranging from 50 to 750 μmol L(r = 0.998), with good precision (r.s.d.

Publication year: 2012 Source: Talanta, Available online 14 February 2012 Christian Frigerio, Vera L.R.G. Abreu, João L.M. Santos A simple and straightforward quantification method integrated in a fully automated multi-pumping flow system (MPFS) using water-soluble mercaptopropionic acid (MPA)-capped CdTe quantum dots (QDs) was implemented for the fluorescence quantification ofN-acetyl-L-cysteine (NAC) in pharmaceutical formulations. The developed approach was based on NAC ability to establish surface interactions that result in enhanced nanocrystals fluorescence intensity, proportional to analyte concentration. Size and concentration of QDs, ageing, composition, concentration and pH of the buffer solution revealed to have a noticeable effect on the enhancing efficiency affecting sensitivity and linear working range of the methodology.Under the optimal conditions, a linear working range was obtained for NAC concentrations ranging from 50 to 750 μmol L(r = 0.998), with good precision (r.s.d.

View original post here:
Evaluation of acetylcysteine promoting effect on CdTe nanocrystals photoluminescence by using a multipumping flow system