Publication year: 2011 Source: Seminars in Cancer Biology, Available online 16 September 2011 Anabelle Decottignies, Fabrizio d’Adda di Fagagna Cellular senescence is eminently characterized by a permanent cell cycle arrest and the acquisition of morphological, physiological and epigenetic changes. The establishment of cellular senescence can occur in response to telomere attrition associated with cell turnover and ageing or following oncogene activation. Although seemingly two distinct phenomena, cellular senescence and cancer share similarly altered global epigenetic profiles comprising changes in DNA methylation, involving global hypomethylation of repetitive DNA sequences and regional hypermethylation of some gene promoters, and in histone post-translational modifications.
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Epigenetic alterations associated with cellular senescen a barrier against tumorigenesis or a red carpet for cancer?