Publication year: 2011 Source: Cellular Signalling, Available online 1 October 2011 Gurdeep Marwarha, Bhanu Dasari, Othman Ghribi Epidemiological studies have suggested an inverse relationship between the adipocytokine leptin and the onset of Alzheimer’s disease (AD), and leptin supplementation decreases amyloid-β (Aβ) production and tau phosphorylation (p-tau), two major biochemical events that play a key role in the pathogenesis of AD. We have previously shown that the cholesterol oxidized product 27-hydroxycholesterol (27-OHC) inhibits leptin expression, an effect that correlated with increased levels of Aβ and p-tau
Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the…
Publication year: 2011 Source: Cellular Signalling, Available online 1 October 2011 Gurdeep Marwarha, Bhanu Dasari, Othman Ghribi Epidemiological studies have suggested an inverse relationship between the adipocytokine leptin and the onset of Alzheimer’s disease (AD), and leptin supplementation decreases amyloid-β (Aβ) production and tau phosphorylation (p-tau), two major biochemical events that play a key role in the pathogenesis of AD. We have previously shown that the cholesterol oxidized product 27-hydroxycholesterol (27-OHC) inhibits leptin expression, an effect that correlated with increased levels of Aβ and p-tau