DNA replication fidelity and cancer

Publication year: 2010 Source: Seminars in Cancer Biology, Volume 20, Issue 5, October 2010, Pages 281-293 Bradley D. Preston, Tina M. Albertson, Alan J. Herr Cancer is fueled by mutations and driven by adaptive selection. Normal cells avoid deleterious mutations by replicating their genomes with extraordinary accuracy. Here we review the pathways governing DNA replication fidelity and discuss evidence implicating replication errors (point mutationinstability or PIN) in carcinogenesis

Publication year: 2010 Source: Seminars in Cancer Biology, Volume 20, Issue 5, October 2010, Pages 281-293 Bradley D. Preston, Tina M. Albertson, Alan J. Herr Cancer is fueled by mutations and driven by adaptive selection. Normal cells avoid deleterious mutations by replicating their genomes with extraordinary accuracy. Here we review the pathways governing DNA replication fidelity and discuss evidence implicating replication errors (point mutationinstability or PIN) in carcinogenesis

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DNA replication fidelity and cancer

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