Alternative splicing interference by xenobiotics

Publication year: 2012 Source: Toxicology, Available online 31 January 2012 Emanuela Zaharieva, Kevin Chipman, Matthias Soller The protein coding sequence of most eukaryotic genes (exons) is interrupted by non-coding parts (introns), which are excised in a process termed splicing. To generate a mature messenger RNA (mRNA) hundreds of combinatorial protein-protein and RNA-protein interactions are required to splice out often very large introns with high fidelity and accuracy

Publication year: 2012 Source: Toxicology, Available online 31 January 2012 Emanuela Zaharieva, Kevin Chipman, Matthias Soller The protein coding sequence of most eukaryotic genes (exons) is interrupted by non-coding parts (introns), which are excised in a process termed splicing. To generate a mature messenger RNA (mRNA) hundreds of combinatorial protein-protein and RNA-protein interactions are required to splice out often very large introns with high fidelity and accuracy

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Alternative splicing interference by xenobiotics